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Long-term administration of prophylactic B12 injections is likely to elevate B12 levels, therefore harm management strategies could include - - regular monitoring of B12 levels, preferably 3-6 monthly

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At the same time, the field acknowledges real limitations heterogeneous trial designs, industry-funded studies, and copper's inherent toxicity at higher concentrations that responsible researchers should factor into any study design

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Fourth, well-designed human trials in a specific, measurable indication (rather than broad anti-aging framing) would be needed before any efficacy claim could be made