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Treatment : Minor skin irritation might be managed with topical creams, while severe reactions (like anaphylaxis) require emergency intervention

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This process is vital for tissues like tendons, which naturally have a poor blood supply

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

A.Salto-TellezM.Laurent-PuigP.BardelliA.RolfoC.TaberneroJ.et al (2018)