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This was confirmed to me by my business partner and genius biochemist Nick Andrews, who had the following to say: Chronic administration has been tested and shown to not generate toxic or negative effects while generating the positive effects observed in adipose tissue as well as muscle tissue. My best guess is that this is supported by what has been seen in animal and cell models thus far: 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid

During the micro-needling process, fine needles puncture the skin minimally to produce small, controlled skin damage that stimulates renewed production of elastin and collagen

Vitamins & Hormones

[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

This is typically administered via oral gavage or subcutaneous injection