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The expression of DNMT3, responsible for de novo methylation, is weaker

Data availability The nuclear magnetic resonance and mass spectrometry data are provided in the Supplementary Information

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

For example neurotransmitters, noradrenaline is converted into adrenaline by methylation (Figure 16)

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Nowadays, attempts are being made to develop safer dosages and methods and new trends like novel delivery technologies to reduce undesirable effects