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Int J Radiat Biol 56:837841

In SURMOUNT trials, tirzepatide delivered up to 21% weight loss in adults without diabetes over 72 weeks

This off-label combination has not been studied in clinical trials and could produce additive GI side effects similar to or exceeding those seen with CagriSema

Downregulating TRPML1 or blocking the interaction between TRPML1 and ARL8B can inhibit AKT-driven tumorigenesis by promoting ferroptosis, and enhancing the sensitivity of radiotherapy and immunotherapy