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For treatment of confirmed deficiency , NHS protocols typically involve hydroxocobalamin injections: initially 1mg three times a week for two weeks for those without neurological involvement, followed by maintenance injections every 2-3 months
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By summarizing data from the animal literature, we conclude the mechanisms of curcumin for chronic diseases combined with anxiety/depressive are mainly focused on the following aspects: (1) Anti-inflammatory and antioxidant effects: for diabetes, obesity or pain, curcumin can reduce pro-inflammatory cytokines (TNF-, IL-6) and regulate pathways such as NF-B