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Infection Risk : As with any procedure involving needles, there is a small risk of infection at the infusion site

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doi:10.1038/cdd.2009.107 Kavouras JH, Prandovszky E, Valyi-Nagy K, et al

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A study found a 1.66-fold increase in CYP1A2 activity in smokers of 1120 cigarettes per day, which is reversed after smoking cessation (Tantcheva-Por et al., 1999)