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1 2 British Journal of Haematology

Genetic and Hormonal Factors: Genetic predisposition or hormonal imbalances can facilitate weight gain in some people

Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age

MOTS-c has little human safety data of any kind

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Other than GI-related side effects, patients on semaglutide also report serious side effects, such as kidney problems, pancreatitis, gallbladder disease, hypoglycemia (low blood sugar), and severe allergic reactions