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Decorin increases 302% at 1 nanomolar concentration, and this small proteoglycan regulates collagen synthesis and organization, essentially serving as an architect for proper structural protein arrangement

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doi: 10.1016/j.vph.2018.02.010

A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]

GLP-1/GIP receptor agonism versus NNMT enzyme inhibition