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Serum folate reflects short-term changes in diet and may be altered by recent meals, so fasting for about six hours beforehand is required, and repeated testing is needed to identify true deficiency

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Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]

on the other hand, any non-invasive procedure, later on, would necessitate a laparoscopic management