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10,14 A further action of DMF is to modulate transcription factors that are sensitive to oxidative stress such as hypoxia-inducible-1a and STAT3/STAT1

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It is not designed for human or veterinary use, consumption, injection, or any other application involving living subjects

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However, translational challenges persist, including the lack of pharmacokinetic standardization between oral and intravenous routes, tumor-type-specific response heterogeneity, and incomplete understanding of VCs immunomodulatory dynamics