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Similarly, rapamycin reduces seizures by inhibiting mTOR, a kinase that mediates positive feedback to the VEGF pathway, which decreases BBB leakage and reduces activation of microglia and macrophages (182)

Urdaneta KE, Castillo MA, Montiel N, Semprn-Hernndez N, Antonucci N, Siniscalco D (2018) Autism spectrum disorders: potential neuro-psychopharmacotherapeutic plant-based drugs

There is also a correlation between IL-6 levels, disease severity and ocular surface parameters [68]

Also, glutamate excitotoxicity NMDA-mediated intra-neuronal calcium overload elevates NO synthesis contributing to oxidative stress particularly the production of reactive nitrogen species which are able to cause defects in DNA and protein phosphorylation pathway (85)

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