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The defining difference is the 0.9% benzyl alcohol preservative. Sterile water for injection contains only water no preservatives and is single-use after the vial is opened, because nothing inhibits microbial growth once the seal is broken. Bacteriostatic water contains 0.9% benzyl alcohol, which inhibits bacterial growth and allows the vial to be punctured multiple times across an extended period (typically 28 days from first puncture under standard handling). For multi-dose laboratory peptide reconstitution work, BAC water is the standard diluent

Pathological response following neoadjuvant immunotherapy in mismatch repair-deficient/microsatellite instability-high locally advanced, non-metastatic colorectal cancer

FDA raised concerns about impurities, aggregates, endotoxins and immunogenicity

Systemic effect across multiple sites

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