However, this hypothesis has never been confirmed, and more recent publications have described the presence of this transporter in the luminal membrane of rat brain slices ( 0,+ is a plasma membrane transporter, specific for neutral and basic AAs, with the highest affinity for isoleucine and leucine
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However, similar to GnRH agonist, GnRH antagonist is associated with hypoestrogenic adverse effects, which require the addition of estradiol and norethindrone acetate (add-back therapy) to attenuate the hypoestrogenic effect (Schlaff et al., 2020)
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