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In cultured hippocampal neurons, Dihexa treatment for 5 days induced a near 3-fold increase in the number of actin-enriched spines by 41 spines/50m for Dihexa vs

[sources 11] JunD, a transcription factor, and G9a, a histone methyltransferase enzyme, both oppose the function of FosB and inhibit increases in its expression

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