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[21] [22] [23] [24] [25] Anemia may present with a number of further common symptoms, [21] [26] including hair thinning and loss, early greying of the hair, mouth ulcers, bleeding gums, [22] angular cheilitis, a look of exhaustion with pale and dehydrated or cracked lips and dark circles around the eyes, as well as brittle nails

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doi: 10.1038/mp.2013.155 94 TaoSHRenXQZhangLJLiuMY

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SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux