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Relative telomere length and mitochondrial DNA copy number variation with age: association with plasma folate and vitamin B12. Mitochondrion 51 (2020): 79-87.

It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

A deficiency can creep up gradually, making it easy to dismiss symptoms as stress or simply getting older. However, if left untreated, low B12 levels can lead to serious health issues

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PARPs, involved in DNA repair, consume NAD+ during frequent repair events in older cells