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*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Extended, uninterrupted IGF-1 LR3 use can lead to receptor desensitization and may affect insulin sensitivity over time

195 PotterG

Osteoarthritic joints exhibit dysregulation of core ferroptosis regulators in critical signaling pathways (Ji et al., 2024)

exceeding this limit may lead to Se toxicity (selenosis), characterized by gastrointestinal disturbances, hair loss, and neurological dysfunction [2]

This protective mechanism is very important in organs of detoxification such as the liver and kidneys