Both canonical inhibitors and serpins are important regulators in balancing not just NSP activity, but other serine proteases as well, in both tissues and circulation (92)
This characteristic allows exploratory evaluation of oral administration, although current data indicate that oral bioavailability is presumed lower than parenteral routes
People with non-proliferative diabetic retinopathy requiring acute therapy, proliferative diabetic retinopathy and macular edema have not been studied in the SURPASS program and in studies with other novel agents, so we need to be cautious on initiation of treatment in these populations, especially in those with uncontrolled glycemia
However, each case is assessed individually based on medical necessity, and coverage is subject to approval
Abbreviations The following abbreviations are used in this manuscript: Appendix A Table A1
Injectable BPC-157 from a reputable provider costs around $166-$299 per unit