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The FDA guide on disposing of unused medicines says take-back is preferred because it keeps medicines out of the water supply and away from kids and pets

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Pirfenidone delayed the decrease in eGFR from a median of 0.61 ml/min/1.73 m 2 during the baseline period to 0.45 ml/min/1.73 m 2 but had no effect on proteinuria or blood pressure [220]