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In addition, the histopathological analysis found that Sildenafil, Vardenafil, and Tadalafil-treated rabbits had reduced spermatocyte counts in the testes

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Challenges and future aspects Challenges in the experimental tools to study the exact mechanism of HIV-1-related factors on microglial activation Experimental model limitations: many current models fail to replicate the complex microenvironment of the CNS, which often results in incomplete or potentially misleading interpretations of activation mechanisms