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One possible scenario is the metabolic cofactor NADPH, which is known to be required not only for lipid synthesis but also for the function of antioxidant reductases, such as glutathione reductase (GSR) and thioredoxin reductase (TXNRD) 86

So for years, a study called the Women's Health Initiative, which was one of the largest hormone studies ever done on the planet, was misquoted as stating that an increase in breast cancer was the result of hormone therapy