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Vitamin B12 plays a key role in the functioning of the body, notably in red blood cell formation, cell metabolism, nerve function, and the production of DNA

Collectively, we established that AIEC were pathoadapted to utilize mucosal metabolites associated with health and inflammation for growth and virulence, enabling the transition from symbiont to pathogen in a susceptible host

For the FOXO4-DRI treatment group, 50 M FOXO4-DRI (MCE, HY-P4157) was added to the glucose-free DMEM (Gibco, Catalog #11966-025) medium, followed by 3 h of oxygen-glucose deprivation (OGD) treatment

Exposure to heat can quickly degrade the vitamin, making it less effective

As methionine, ingested as protein in the diet, is the only source of homocysteine, it would be expected that food intake would cause increased concentrations of homocysteine in plasma

PMID: 28286221