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Rights and permissions About this article Cite this article Polonikov, A., Vialykh, E., Churnosov, M
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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]
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