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Continuous use without rest periods is not recommended

In its May 2026 evaluation, the FDA identified one small meeting abstract describing a short randomized study in people with ulcerative colitis

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900 , 901 With regard to cost savings, participation in the original Care Ecosystem program reduced the total cost of care by $3,290 per person from one to six months after enrollment and by $3,027 from seven to 12 months postenrollment, corresponding to a mean monthly cost reduction of $526 across 12 months

997 As noted in the Mortality and Morbidity section, a person who lives from age 70 to age 80 with Alzheimer's dementia will spend an average of 40% of this time in the severe stage