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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

Whether this translates to equivalent results depends on individual factors and goals

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Researchers tracking retatrutide versus semaglutide data and retatrutide dosing protocols will find that this triple agonist could eventually overtake both CagriSema and tirzepatide