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* Correspondence: Hongying Kuang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The process begins with genetic susceptibility, primarily caused by high-risk HLA class II alleles (e.g., HLA-DQ2/DQ8), and is complemented by class I alleles and key non-HLA variants in immunoregulatory genes

Those compounds modulate neurotransmitter levels for immediate performance effects

The details matter because the lungs are a direct delivery surface

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