Novel ALK inhibitors in clinical use and development
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Previously, a direct link between impairments of synapse formation and neurite outgrowth was found in an astrocyte culture with impaired cholesterol biosynthesis [395]
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Mao found that treating cancer cells with GPX4 inhibitors resulted in acute depletion of N-carbamyl-L-aspartate (C-ASP, a pyrimidine biosynthesis intermediate), accompanied by accumulation of uridine, which could be inhibited by fer-1, a ferroptosis inhibitor [18]