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Conflicting results within and across studies highlight the complexity of anxiety-like phenotypes in these models, emphasizing the need for comprehensive behavioral tests to understand underlying mechanisms

Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis (68)

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While it requires focus and a steady hand, most patients find they become comfortable with the process after one or two tries