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Mood Changes and Depression Vitamin B12 plays a key role in the production of serotonin, a neurotransmitter that helps regulate mood

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The figure shows the precursors of L-methylmalonyl-CoA: Fatty acids and amino acids can be metabolized to propionyl-CoA, which is converted to D-methylmalonyl-CoA and then to L-methylmalonyl-CoA

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Low B12 levels are associated with brain lesions, spinal cord degeneration, cognitive disorders, motor sensory dysfunction and damage to the optic nerves

Instead, focus on comprehensive plans that combine sustainable diet changes, activity, behavior support, and, when appropriate, medical options that have robust human trial evidence