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However, physiological concentrations of 1 to 10 mg/mL peptide were measured in leukocytes and in the lumen of crypts of Lieberkhn and have been shown to kill microorganisms in vitro at physiological salt concentrations [132]

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Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations

GHS-R1a engagement activates Gq/11 proteins, stimulating phospholipase Cmediated hydrolysis of PIP2 to IP3 and DAG, leading to intracellular Ca mobilisation and activation of somatotroph secretory machinery