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Moreover, UA can form stable complexes with metal ions such as iron and copper, converting them into less reactive forms, thereby preventing them from catalyzing free radical reactions [39]

It is commonly used to improve focus, reduce fatigue, support recovery from burnout or illness, and promote healthy ageing at the cellular level

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4.5 Gutkidney axis regulation The gutkidney axis refers to the bidirectional interaction between the intestinal microbiota and the kidneys, which plays an increasingly recognized role in CKD progression ( Vitamin D, via the VDR regulates intestinal epithelial and mucosal immune cells, contributing to barrier maintenance and microbial homeostasis

Accordingly, GPx1-KO mice had significantly lower intestinal GPx activity than the wild-type mice before exposure to -irradiation