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These changes may reflect reduced nutrition, frequent wet work, thyroid disease, eczema, psoriasis, fungal infection or anaemia

The ANT crystal structures in both cytoplasmic-open (c-state) and matrix-open states (m-state) locked by two inhibitors bound at the solute binding site, carboxyatractyloside and bongkrekic acid respectively, highlighted a conserved alternating-access transport mechanism 5 enabled by the conformational change upon solute binding at the central cavity 6,7

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For instance, changes in the composition of this phospholipid layer have been observed by researchers, along with their detrimental effects on the bones and joints of individuals with OA

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