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10.1016/j.jep.2016.08.040 198 YaoJ.WangJ.XuY.GuoQ.SunY.LiuJ.et al (2022)

C408 sits behind a positively charged wall formed largely by the side chains of R370 and R413

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However, as of now, the FDA has approved GLP-1 drugs only in the form of injections and pills 1 , 2 , and there are no approved form of GLP-1 transdermal (skin) patches which are in medical use

Yuan L, Sheng X, Clark LH, Zhang L, Guo H, Jones HM, Willson AK, Gehrig PA, Zhou C, Bae-Jump VL