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Biochem Pharmacol (2021) 190:114661

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Elevated blood sugar levels impair vasodilation by activating PKC in vascular cells, affecting the activities of ET-1, VEGF, NO, PDGF, ROS, and NF-B in pericytes, leading to capillary myelopoietic thickening and increased endothelial cell proliferation (Liu et al

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Interestingly, the relatively higher abundance of polysaccharide-degrading taxa such as Prevotella in the duodenum compared to the jejunum and ileum may reflect passive transfer from the rumen rather than indigenous colonization, highlighting the role of the small intestine as a transitional zone in the digestive continuum 73

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