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Tfr1 mediates the uptake of iron bound to transferrin, while transferrin facilitates the excretion of iron from cells (58, 59)

Although the role of LCN2 in downregulating SLC7A11 has not been extensively studied in depression, LCN2 upregulation and SLC7A11 downregulation were observed in streptozotocin (HFD-STZ)-induced mice, contributing to neuronal loss and cognitive dysfunction (Xie et al., 2023)

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When we are young, this process is robust, but aging, chronic disease, poor circulation, and repetitive injuries can create an environment that impairs the bodys ability to heal