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When administered subcutaneously (just under the skin) or intramuscularly (into the muscle), the peptide enters the bloodstream more directly, bypassing the digestive system entirely

Second, hyperhomocysteinemia detected only by the oral methionine-loading test (approximately 27% of patients), which might mainly result from an inhibition of the transsulfuration pathway (vitamin B 6 deficiency or heterozygous CBS defect), and which increases the risk 1.5-fold

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Weaknesses of our study include reliance on self-reported symptoms and diagnoses such as cough and acute exacerbations of COPD, the transient nature of HHs on imaging, and our relatively small sample size