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More recent controlled trials confirm it improves wrinkles, dermal density, and firmness over 12-24 weeks, with significant improvements in skin texture and firmness (particularly with the higher 0.1% concentration)

Western blot (WB) confirmed that H3K18R reduced intracellular H3K18la levels to some extent, validating the effectiveness of this approach in porcine granulosa cells (Supplementary Fig

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