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It tells me that with a small intervention, just by activating the sirtuins, you can mimic fasting, he concluded

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Estradiol reduces pituitary responsiveness to somatostatin (SRIF14) and downregulates the expression of somatostatin sst2 receptors in female goldfish pituitary

Cooper AJL, Jeitner TM (2016) Central role of glutamate metabolism in the maintenance of nitrogen homeostasis in normal and hyperammonemic brain