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They stimulate fibroblasts , the cells responsible for producing collagen and elastin , which are crucial for skin firmness and elasticity
However, due to the rising rates of adolescent obesity in industrialized countries there is an increasing incidence of type 2 diabetes in pre- and postpubescent children
Marques AC, Vinckenbosch N, Brawand D, Kaessmann H (2008) Functional diversification of duplicate genes through subcellular adaptation of encoded proteins
doi: 10.1038/s41577-019-0228-2 160 LiuSPanYLiTZouMLiuWLiQet al
PGC-1 upregulates the expression of GLUT4 in skeletal muscle [103,104,105], inhibits pro-inflammatory cytokine production [106], and is a co-activator of the retinoic X receptor (RXR) [83,85,107]
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