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Furthermore, obesity and T2DM lead to systemic inflammation, increasing pro-inflammatory brain cytokines, which may, in turn, interfere with insulin signaling and neurotransmission [92]

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The spread and the efficiency were similar to other striatal lentiviral transductions reported in the literature 72,73

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Several polyphenols have been shown to modulate sirtuin 1 signaling pathway and regulate key cell processes, such as cell cycle, DNA repair, protein aggregation, inflammation, and mitochondrial function [88]