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It is well-recognized that the PK and exposure-response relationships of drugs can differ widely between children and adults ( Table 1 displays the difference in the median weight from cohort A to cohorts B/C

Yang JZ, Jiang X, Dong J, Guo J, Chen H, Tsang LL, Chung YW, Zhang X, Chan HC (2011) Abnormally enhanced cystic fibrosis transmembrane conductance regulator-mediated apoptosis in endometrial cells contributes to impaired embryo implantation in controlled ovarian hyperstimulation

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Many high-impact outcome claims come from small studies or community reports rather than large RCTs