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Consider B 12 supplementation without testing in asymptomatic patients with risk factors for B 12 deficiency (see Table 1: Patient Risk Factors Associated with B 12 Deficiency)

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Cycle length is typically 4 to 8 weeks, with a clinical review at the midpoint to assess response

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Induction of hormone-sensitive lipase/cholesteryl esterase gene expression by C/EBP independently of the PKA pathway in the adrenocortical Y-1 cells

For non-reversible treatments, we under-treat first by design and add more at follow-up