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UA treatment provides antioxidant protection to dopaminergic cells by reducing Nrf2 ubiquitination and degradation and promoting its nuclear translocation, leading to transcription and expression of Nrf2-targeted antioxidant genes [175](Fig

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Importantly, the announcement does not indicate that the peptides will be placed on the Category 1 May Compound list, possibly leaving those bulk drug substances in limbo unless the FDA announces enforcement discretion with regard to the substances