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In specific embodiments, the deliverable osmolarity/osmolality of the formulations (i.e., the osmolarity/osmolality of the formulation in the absence of gelling or thickening agents (e.g., thermoreversible gel polymers) is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of potassium or sodium salts) or the use of tonicity agents which renders the formulations endolymph-compatible and/or perilymph-compatible (i.e

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The gene expression profiles of WT and RAMP1/3 KO mice across the different treatment groups in the MBH, DVC, and LPBN in comparison with the vehicle-treated WT group revealed distinct patterns

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