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PMID: 9617990

Favorable Safety and Tolerability Profile Evidence: Strong (human and animal data) While not a "benefit" in the traditional sense, ipamorelin's safety profile is itself a meaningful advantage

In human specimens and OA models established via surgery such as the DMM model or ACLT, immunohistochemical or Western blot analyses of OA cartilage and synovial tissues show significantly lower GPX4 expression in lesioned areas compared to adjacent relatively normal tissues or normal control mice and patients

Proceedings of the Seminars in pediatric neurology

However, this doesn't mean copper accumulation is impossible, particularly with long-term use or in individuals with impaired copper metabolism

The disparity by sex is high in most of these diseases with a female preponderance of 85%