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Two reasons are commonly cited: preventing receptor desensitization and avoiding copper accumulation

131 In a few instances, leukocyte dysfunction associated with Class I variant G6PD deficiency has been described

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Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA