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We discuss the latest evidence that highlights tight junction components, structures and regulatory mechanisms, their impact on gut health and disease, and opportunities for therapeutic intervention

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Excessive metabolization of ATP to ADP may determine the course of inflammation

The same authors found that the L-tyrosine analogue (S)--fluoromethyltyrosine (AFMT), a nontoxic selective inhibitor of TDC (but not AADC), inhibited gut microbial levodopa decarboxylation in vitro