Thus, increased Nrf2 activity does not initiate cancer development but confers advantages in terms of proliferation and stress resistance once a cell acquires uncontrolled proliferative properties
Navid F, Colbert RA (2017) Causes and consequences of endoplasmic reticulum stress in rheumatic disease
Balakumar, P., Rohilla, A., Krishan, P., Solairaj, P
491,493 A recent study suggests that Ni II -specific binding couples an allosteric network of residues at an interface between the DNA binding and metal binding domains (Figure 16B), which in turn, appears to result in an increase in protein rigidity, locking NikR in a DNA binding-active conformation
In line with this, the antiviral activity of compound-17 is not impeded by increased intracellular glutathione levels, consistent with inhibition of a stage of the infection process which occurs before virus assembly in the cytoplasm, such as uncoating in the endosome
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