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Viral-induced IL-6 acts synergistically with interleukin-1 (IL-1) and tumor necrosis factor- (TNF) to degrade the extracellular matrix (ECM), worsening inflammation, which has been linked to increased disease morbidity in COVID-19 [68]

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Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners

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To stop signal transduction, Kdm2a/b competes with TCF/LEF for -catenin binding and removes methyl markers from -catenin, which is subsequently degraded via ubiquitination

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